S100B, S100 calcium binding protein B, 6285

N. diseases: 599; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Serum S100B can be used as a biomarker of depression. 30745657 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Serum S100B can be used as a biomarker of depression. 30745657 2020
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 AlteredExpression disease BEFREE These data suggest that ethnicity or race should be given serious consideration when studying and interpreting S100b levels in persons with schizophrenia. 31786729 2020
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Shave biopsy and immunohistochemical studies revealed that the tumor was composed of malignant melanoma (MM) (highlighted by S100 and MART-1) intermixed with squamous cell carcinoma (SCC) (highlighted by cytokeratin and p63), and a diagnosis of combined MM-SCC was rendered. 31361351 2020
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE S100, human melanoma black 45, and melanoma antigen recognized by t-cell (Melan A) were negative. 30978337 2020
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker phenotype BEFREE Mts1 is a member of the S100 protein family and is involved in tumor progression and metastasis. 31467231 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE However, few S-100 positive lipoblasts suggested the origin of the tumor. 31796335 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Shave biopsy and immunohistochemical studies revealed that the tumor was composed of malignant melanoma (MM) (highlighted by S100 and MART-1) intermixed with squamous cell carcinoma (SCC) (highlighted by cytokeratin and p63), and a diagnosis of combined MM-SCC was rendered. 31361351 2020
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.100 Biomarker phenotype BEFREE Serum S100B can be used as a biomarker of depression. 30745657 2020
CUI: C0011206
Disease: Delirium
Delirium
0.080 AlteredExpression disease BEFREE After adjusting for age, gender, Acute Physiology and Chronic Health Evaluation II score, Charlson comorbidity score, sepsis diagnosis and study intervention group, interleukin-6, -8, and -10, tumor necrosis factor-α, C-reactive protein, and S-100β levels in quartile 4 were negatively associated with delirium-/coma-free days by 1 week and 30 days post enrollment. 31770149 2020
CUI: C0011206
Disease: Delirium
Delirium
0.080 Biomarker disease BEFREE We measured the independent associations between intraoperative F2-isoprostanes and isofurans and delirium (primary outcome) and postoperative ubiquitin carboxyl-terminal hydrolase isozyme L1 (secondary outcome), and we assessed if S100 calcium-binding protein B modified these associations. 31770146 2020
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.080 Biomarker phenotype BEFREE Mts1 is a member of the S100 protein family and is involved in tumor progression and metastasis. 31467231 2020
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders
0.080 AlteredExpression group BEFREE Alterations of S100B level were noted in various neurodegenerative diseases. 31705442 2020
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.050 GeneticVariation disease BEFREE Association of S100B polymorphisms and serum S100B with risk of systemic lupus erythematous in a Chinese population. 31271591 2020
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.030 Biomarker disease BEFREE Shave biopsy and immunohistochemical studies revealed that the tumor was composed of malignant melanoma (MM) (highlighted by S100 and MART-1) intermixed with squamous cell carcinoma (SCC) (highlighted by cytokeratin and p63), and a diagnosis of combined MM-SCC was rendered. 31361351 2020
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.030 Biomarker disease BEFREE The inhibition of S100B release or microglia response could potentially decrease the damage in degenerative diseases, like glaucoma. 31705442 2020
Systemic onset juvenile chronic arthritis
0.030 Biomarker disease BEFREE We aimed to examine IL-18 levels in sJIA in relation to disease activity and history of MAS and other disease biomarkers namely S100 proteins and CXCL9. 31326996 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.020 Biomarker disease BEFREE Also, serum levels of S100A4, S100A8/S100A9, S100A12, and S100B correlate with insulin resistance/type 2 diabetes, metabolic risk score, and fat cell size. 31363816 2020
CUI: C0028754
Disease: Obesity
Obesity
0.020 Biomarker disease BEFREE Certain S100 proteins, namely S100A4, the S100A8/S100A9 heterodimer and S100B, have been implicated in the pathophysiology of obesity-promoting macrophage-based inflammation via toll-like receptor 4 and/or receptor for advanced glycation end-products ligation. 31363816 2020
CUI: C2825741
Disease: Indeterminate dendritic cell tumor
Indeterminate dendritic cell tumor
0.020 Biomarker disease BEFREE Diffuse dermal infiltration of a mixture of histiocytes and lymphocytes accompanied with multinuclear giant cells, the positive CD68 and Factor XIIIa and negative Langerin immunoreactions, along with the positive staining with CD1a and S100, led us to the diagnosis of ICH. 31789127 2020
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.010 AlteredExpression disease BEFREE The increased postoperative NSE and S100B levels in the IIFG group compared with controls may be associated with severe insulin resistance and stress hyperglycemia. 30430888 2020
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.010 GeneticVariation disease BEFREE Association of S100B polymorphisms and serum S100B with risk of systemic lupus erythematous in a Chinese population. 31271591 2020
CUI: C0024138
Disease: Lupus Erythematosus, Discoid
Lupus Erythematosus, Discoid
0.010 GeneticVariation disease BEFREE Association of S100B polymorphisms and serum S100B with risk of systemic lupus erythematous in a Chinese population. 31271591 2020
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
0.010 AlteredExpression disease BEFREE S100-A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF-κB pathway in polycystic ovary syndrome. 31568644 2020
CUI: C0154830
Disease: Proliferative diabetic retinopathy
Proliferative diabetic retinopathy
0.010 AlteredExpression disease BEFREE Assessment of neuron-specific enolase, S100B and malondialdehyde levels in serum and vitreous of patients with proliferative diabetic retinopathy. 31571092 2020